Bioventus Surgical - a broad portfolio of biologic solutions

At Bioventus Surgical, we are driven to advance the science and surgical performance of orthobiologics with a comprehensive portfolio of clinically efficacious and cost-effective solutions.  Our comprehensive portfolio of surgical orthobiologics offers a wide variety of bone graft solutions to meet the needs of any surgeon across a broad range of patient needs, procedures, and hardware selection. 

Bioventus has a range of allograft solutions which provide osteoconductive and osteoinductive properties to aid the natural bone healing process in OSTEOAMP, EXPONENT, and PUREBONE.

Bioventus provides revolutionary and standard cell and marrow aspiration needles used to harvest bone marrow aspirate complementing bone graft substitutes with CELLXTRACT and EXTRACTOR.

Bioventus has a range of bioactive and biphasic synthetics in SIGNAFUSE, INTERFACE, and OSTEOMATRIX+ that combine select materials providing osteoconductive and osteostimulatory scaffolds and excellent handling capabilities.
 

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Brands: OSTEOAMP, SIGNAFUSE, CELLXTRACT, EXPONENT, PUREBONE, EXTRACTOR, INTERFACE, OSTEOMATRIX+, INTERFACE


 Videos

OSTEOAMP SELECT Fibers Handling
Dr. Paul Kim: Application and Delivery of a Versatile Bone Graft
Dr. Raymond Hwang: MIS TLIF Case Review Video
SIGNAFUSE Strip Video
Dr. Khoi Than: LLIF and ALIF Case Reviews
Spinal Fusion Series: Use of OSTEOAMP, a Novel Allograft, in a Variety of Complex Procedures

 Press Releases

  • DURHAM, NC – September 2, 2020 – Bioventus is sharing results of the first in-patient use of its new SIGNAFUSE Bioactive Bone Graft strips. Rick Placide, M.D. of VCU Health in Richmond, VA, performed a posterolateral lumbar fusion (PLF) and placed the SIGNAFUSE strips in the posterolateral gutters of the patient’s spine.

    “Since the recent release of the SIGNAFUSE strip, we have used it as a bone graft extender in several cases and found it easy to use,” remarked Dr. Placide. “We have already been impressed by its ability to absorb bone marrow aspirate while maintaining its form, flexibility and toughness. These properties make SIGNAFUSE strips ideal for a variety of cases, including spanning large defects. We look forward to following the clinical outcomes.”

    SIGNAFUSE strips were designed with the patient in mind. They come in multiple sizes ranging from 25 to 200 millimeters in length, allowing utilization over multiple levels like we saw in Dr. Placide’s deformity application case,” said Lawrence Boyd PhD, Vice President, Product Development, Bioventus. “There are benefits for the surgeon as well: these strips hydrate rapidly and provide exceptional handling properties for intraoperative flexibility.”

    100mm-SIGNAFUSE-Strips-used-on-each-side-of-a-4-level-posterolateral-lumbar-fusion.

    The new strip format of SIGNAFUSE is available now from Bioventus distributors nationwide.

    About Bioventus

    Bioventus delivers clinically proven, cost-effective products that help people heal quickly and safely. Its mission is to make a difference by helping patients resume and enjoy active lives. The orthobiologic products from Bioventus include offerings for osteoarthritis, surgical and non-surgical bone healing. Built on a commitment to high quality standards, evidence-based medicine and strong ethical behavior, Bioventus is a trusted partner for physicians worldwide. For more information, visit www.bioventus.com and follow the company on LinkedIn and Twitter.

    Media Contact: Thomas Hill, 919-474-6715, thomas.hill@bioventusglobal.com

    Bioventus, the Bioventus logo and SIGNAFUSE are registered trademarks of Bioventus LLC.

    Summary of Indications for Use
    SIGNAFUSE Bioactive Bone Graft is a bone graft substitute intended for use in bony voids or gaps of the skeletal system not intrinsic to the stability of the bony structure. These osseous defects may be surgically created or result from traumatic injury to the bone. SIGNAFUSE Bioactive Bone Graft is indicated to be combined with autologous bone marrow aspirate and packed into osseous defects of the extremities, pelvis and posterolateral spine. When used in the posterolateral spine, SIGNAFUSE Bioactive Bone Graft is to be used as an autograft extender. The device resorbs and is replaced by host bone during the healing process.

  • DURHAM, NC – June 25, 2020 – Bioventus, a global leader in orthobiologic solutions, is launching its SIGNAFUSE Bioactive Bone Graft in a new strip format. The strips consist of 55% bioglass by weight and have been shown to induce higher levels of osteoblast differentiation compared to other synthetic bone graft strips.1

    SIGNAFUSE has been available as a putty since 2014; the new strips hydrate rapidly and provide exceptional handling properties for intraoperative flexibility.  They come in multiple sizes ranging from 25 to 200 millimeters in length, with the longer strips providing a great option for large, multilevel procedures.

    The biphasic mineral in SIGNAFUSE is composed of 60% hydroxyapatite and 40% beta-tricalcium phosphate; a ratio supported by multiple prospective2 and randomized controlled trials.3-5

    “We are excited to expand our portfolio of bone graft solutions with the SIGNAFUSE Bioactive Bone Graft strip,” said Megan Osorio, Vice President, Marketing, Bioventus. “Apart from the ideal combination of biomaterials that contribute to healing, and best-in-class handling, this product is unique in that it offers a great solution for patients that require more significant interventions such as spinal deformity correction.”

    “We also believe SIGNAFUSE in the strip format will provide efficiencies for the hospital, either by opening fewer packages or cost savings opportunities vs. alternative grafts,” added John Nosenzo, Chief Commercial Officer, Bioventus.

    The new strip format of SIGNAFUSE will be available in Q3 from our distributor partners across the country.

    About Bioventus

    Bioventus is an orthobiologics company that delivers clinically proven, cost-effective products that help people heal quickly and safely. Its mission is to make a difference by helping patients resume and enjoy active lives. The orthobiologic products from Bioventus include offerings for osteoarthritis, surgical and non-surgical bone healing. Built on a commitment to high quality standards, evidence-based medicine and strong ethical behavior, Bioventus is a trusted partner for physicians worldwide. For more information, visit www.bioventus.com and follow the company on LinkedIn and Twitter.

    Media Contact: Thomas Hill, 919-474-6715, thomas.hill@bioventusglobal.com

    Bioventus, the Bioventus logo and SIGNAFUSE are registered trademarks of Bioventus LLC.

    Summary of Indications for Use
    SIGNAFUSE Bioactive Bone Graft is a bone graft substitute intended for use in bony voids or gaps of the skeletal system not intrinsic to the stability of the bony structure. These osseous defects may be surgically created or result from traumatic injury to the bone. SIGNAFUSE Bioactive Bone Graft is indicated to be combined with autologous bone marrow aspirate and packed into osseous defects of the extremities, pelvis and posterolateral spine. When used in the posterolateral spine, SIGNAFUSE Bioactive Bone Graft is to be used as an autograft extender. The device resorbs and is replaced by host bone during the healing process.

    1. Data on file. RPT-000962. Osteoblast Differentiation Study. 2. Cavagna R, Daculsi G, Bouler JM. Macroporous calcium phosphate ceramic: a prospective study of 106 cases in lumbar spinal fusion. J Long-Term Effects Med Implants, 1999;9:403-12. 3. Ransford AO, Morley T, Edgar MA, et al. Synthetic porous ceramic compared with autograft in scoliosis surgery. A prospective, randomized study of 341 patients. J Bone Joint Surg Br. 1998;80-B:13-8. doi: 10.1302/0301-620x.80b1.7276 4. Delécrin J, Takahashi S, Gouin F, Passuti N. A synthetic porous ceramic as a bone graft substitute in the surgical management of scoliosis: a prospective, randomized study. Spine (Phila Pa 1976). 2000;25(5):563-9. doi: 10.1097/00007632-200003010-00006 5. Pascal-Moussellard H, Catonné Y, Robert R, Daculsi G. Anterior cervical fusion with PEEK cages: clinical results of a prospective, comparative, multicenter and randomized study comparing iliac graft and a macroporous biphasic calcium phosphate. Spine J. 2006;6(suppl 5):136S. Abstract P109. doi: 10.1016/j.spinee.2006.06.318

 Featured Products

  • OSTEOAMP SELECT
    Simple. Yet Sophisticated. ...

  • OSTEOAMP SELECT Fibers format are an innovative addition to the OSTEOAMP portfolio

     

    OSTEOAMP SELECT Fibers provide nano-level surface properties and exceptional handling, and are manufactured with the unique OSTEOAMP process which has been shown to retain up to 23 different growth factors that support new bone formation

     

    • Retains essential growth factors supporting bone formation
    • Structurally entangled fibers provide versatile handling
    • Has high fluid retention and ability to expand
    • Interlocking fibers maintain integrity and position
    • Nanotextured fibers provide a conduit for cell migration


     

    Click Here to Learn More About OSTEOAMP SELECT Fibers

     

  • SIGNAFUSE
    Activating Cells to Signal Fusion...

  • SIGNAFUSE contains a synergistic combination of biomaterials that supports new bone formation

     

    SIGNAFUSE is a synthetic bone graft made up of bioglass and a biphasic mineral (60% hydroxyapatite, 40% β-tricalcium phosphate) available in putty and strip formats. 

     

    Supported by Clinical Data
    In a recent study, the SIGNAFUSE Strip induced higher levels of osteoblast differentiation compared to other synthetic bone graft strips. The unique and synergistic combination of biomaterials in SIGNAFUSE helps accelerate cellular activity and kickstart osteogenesis.


     

    The biphasic mineral in SIGNAFUSE is composed of 60% hydroxyapatite and 40% β-tricalcium phosphate,a ratio shown to be safe and effective by multiple prospective and randomized controlled trials.


     

    Click Here to Learn More About SIGNAFUSE

  • CellXtract
    High Quality Cells Without Compromise....

  • Bone Marrow Aspirate Without Dilution or Centrifugation

     

    CELLXTRACT provides high levels of cells and their associated signals to deliver optimum clinical results.

     

    The CELLXTRACT Difference

    • Independently reviewed clinical data shows the number of stem cells collected by CELLXTRACT, as counted by fibroblast-like colony-forming units (CFU-f), are greater than aspirations from a standard needle of similar volumes and is comparable or greater than final products after centrifugation.
    • Autologous bone marrow aspirate (BMA) contains the needed cells and growth factors to enhance bone healing.
    • There is no waste of biologic material or discard of viable cells compared to inherent inefficiencies in centrifuge-based systems.
     

    Economics

    • Potential savings can be realized as compared to the centrifuge-based competitors. Generally, the cost of CELLXTRACT is less than the disposable kit associated with those systems.
    • No additional personnel is needed to operate equipment as no centrifugation is required.
     

    Safety

    • The aspirated fluid is not required to leave the sterile field for centrifugation, creating less risk for contamination or infection.
    • Traditional needles require repositioning via an additional insertion point(s) or angling in order to access a fresh channel of BMA increasing the risk of infection, blood loss, and operative time. CELLXTRACT, on the other hand, only requires one insertion point minimizing the risks to the patient.

     

    To Learn More About CELLXTRACT, Click Here

     

  • OSTEOAMP
    Closer to Autograft Than Ever Before...


  • The OSTEOAMP Difference

     

    Our proprietary method of processing bone and bone marrow makes OSTEOAMP different from demineralized bone matrix (DBM) products that strip away bone marrow during processing, which reduces their potential for initiating osteoinduction and angiogenesis.

     

    OSTEOAMP is available in multiple, easy-to-use formats that meet the unique needs of surgeons across a broad range of patients, procedures and hardware selection. These formats include compressible sponges, fibers, granules and putty. All OSTEOAMP formats have a 5-year shelf-life, are freeze-dried, shelf stable at room temperature, and do not require any special shipping, storage or defrosting.

     

    OSTEOAMP has been shown to retain up to 23 natural growth factors that support bone formation


     

  • EXPONENT
    Demineralized Bone Matrix...

  • EXPONENT provides an osteoconductive scaffold with osteoinductive potential while providing optimal handling characteristics, and combines 30% demineralized human allograft bone by weight with a resorbable, migration-resistant carrier.


    The EXPONENT Difference

     
    • EXPONENT features an osteoconductive matrix with osteoinductive potential that provides a natural scaffold for cellular ingrowth and revascularization.
    • EXPONENT has the osteoconductive ability to grow bone as fully characterized in an in vivo rabbit spinal model.
    • Each lot of EXPONENT is evaluated for osteoinductive potential using a validated in vitro assay.
     


    Pliable and Cohesive Composition

     
    • EXPONENT is formulated as a putty that is ready-to-use out of the syringe.
    • EXPONENT is highly malleable and easy to mold and pack into the surgical defect.
       

    Safety

     
    • Donor bone is sourced from AATB-certified and FDA-registered tissue banks in the United States.
    • All tissues are screened for the standard panel of infectious viruses.
    • Manufacturing and sterilization processes have been validated to inactivate HIV-1, Bovine Herpes Virus (BHV), Bovine Viral Diarrhea Virus (BVDV), Hepatitis A Virus (HAV) and Porcine Parvovirus (PPV).
       
     

    To Learn More About Exponent, Click Here


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